how many serotypes of dengue virus

Dengue human infection models to advance dengue vaccine development. Conclusions: 370(9599):1644-52. Am J Trop Med Hyg. [Full Text]. This epidemiologic observation can be explained by the theory of immune enhancement. 2007 Apr 28. Contributed articles. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Beatty ME, Beutels P, Meltzer MI, et al. Circulation of DENV-1, DENV-2, and DENV-3 was reported in northern and coastal Kenya during 2011–2014 (13). [Full Text]. Ten threats to global health in 2019. Edelman R. Dengue vaccines approach the finish line. Available at http://www.who.int/mediacentre/factsheets/fs117/en/. Am J Trop Med Hyg. The dengue vaccine, called Dengvaxia, was introduced to Mexico in 2015, and was intended to work on a three-dose schedule. Available at http://www.cdc.gov/Dengue/travelOutbreaks/. 2u; 6: Sample no. [Medline]. [Medline]. 13. Dengue is a disease caused by a RNA virus of the family Flaviviridae, caused by four serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which are genetically and antigenically distinct. Science. [Medline]. Dengue is also known as Breakbone Fever, Hemorrhagic Fever, Dandy Fever, Infectious Thrombocytopenic Purpura. Infect Dis Clin North Am. Green S, Rothman A. Immunopathological mechanisms in dengue and dengue hemorrhagic fever. There are four different strains (serotypes) of the dengue virus. Numbers at nodes represent... We provide phylogenetic relationships of 31 DENV sequences, including 7 whole genomes, from the current study (Figures 4,5,6,7). doi: 10.1371/journal.pone.0154760. Majority of the combined infections were caused by dengue serotype 2 and 3. Serum levels of cytokines in two ethnic groups with dengue virus infection. 2000 Mar. Found insideEmerging Infections is the first volume of the new Biomedical Research Reports Series, which will provide annual updates on hot topics of interest to a broad spectrum of the biomedical research community. Available at [Full Text]. Reinfestation by Aedes aegypti in the Americas after the 1970 (left) mosquito eradication program and most recent distribution as of 2002 (right). There are four different serotypes of the dengue virus, which means that you can get infected with dengue four times. Dengue and dengue hemorrhagic fever occur in epidemic and endemic form throughout tropical areas of the world. 2008. World Health Organization. Semin Nephrol. 2008 Nov. 79(5):673-7. M: 100 bp DNA ladder…, Gel photograph of sample no. 2011 Feb. 84(2):224-8. 2008 Sep 24. Overall, girls were less represented than boys (467/1,022, 45.7%), and this trend was consistent across sites (44.5% girls in the coastal region, 46.5% girls in the western region). BMC Infect Dis. Wagner D, de With K, Huzly D, Hufert F, Weidmann M, Breisinger S, et al. Dengue is caused by virus of Flaviviridae family, and there are 4 distinct, but closely related, serotypes that cause dengue (DENV‐1, DENV‐2, DENV‐3, and DENV‐4). Overall dengue virus serotypes 2 and 3 were the major outbreak-causing serotypes in Pakistan in 2011 and 2013. 2016 May 23;11(5):e0154760. Overall dengue virus serotypes 2 and 3 were the major outbreak-causing serotypes in Pakistan in 2011 and 2013. The incidence of dengue in Pakistan in past years mainly restricted to parts of Sindh and Punjab provinces. Multiple sequence alignment of both partial and complete genome sequences was performed by using the Multiple Alignment and Fast Fourier Transform plug-in in Geneious Prime 2020.0.5 (https://www.geneious.com). Curr Opin Infect Dis. Subsequent infections of other serotypes tend to be more severe. The prognosis for dengue is usually good. All 4 dengue virus serotypes were detected, and phylogenetic analyses showed several viruses from novel lineages. Indian J Med Microbiol. Dengue disease severity in Indonesian children: an evaluation of the World Health Organization classification system. Postgrad Med J. J Virol Methods. Geneva: World Health Organization; 1997. Dengue virus (DENV, shown in Fig.1) can cause dengue fever. The editors have built Flavivirus—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you ... Development of a live attenuated dengue virus vaccine using reverse genetics. Please enable it to take advantage of the complete set of features! Dengue virus detection using whole blood for reverse transcriptase PCR and virus isolation. We obtained detailed clinical histories and performed physical examinations. A complex interplay among virus, dendritic cells, T cells, and cytokines in dengue virus infections. Viral Immunol. [Medline]. Recent analyses suggest that antigenic heterogeneity may exist within each serotype, but its source, extent and impact remain unclear. Aedes albopictus. 2012. doi:10.1056/NEJMra1110265. Among all 1,022 study participants, 419 (41.0%) were given an antimalarial. Single-reaction multiplex reverse transcription PCR for detection of Zika, chikungunya, and dengue viruses. There are 4 distinct serotypes (DENV-1 to DENV-4), and … [Medline]. The first licensed dengue vaccine, CYD-TDV, is a chimeric dengue-yellow fever virus 17D (YF17D) vaccine that was constructed by replacing the prM/E RNA sequences of YF17D with corresponding sequences of the DENV-1–4 serotypes (Guy et al., 2010).Data from phase III trials revealed that vaccine efficacy varies depending on age, serotype, and serostatus, and a low vaccine … 2015 Sep 28. Global map of dengue risk. [Medline]. Bennett), École Normale Supérieure de Lyon, Lyon, France (J. Hortion), The global distribution of the arbovirus vectors. Circulating serotypes of dengue virus; Dengue Pakistan; Dengue infection; Epidemiology of dengue; Khyber Pakhtunkhwa; Swat. [Medline]. [Medline]. 14(1):121-40, ix. [Medline]. Careers. The Altmetric Attention Score for a research output provides an indicator of the amount of attention that it has received. Aw PPK, de Sessions PF, Wilm A, Hoang LT, Nagarajan N, Sessions OM, et al. It also raises the possibility of immunological cross-reactivity between dengue's Flavivirus serotypes (dengue antibodies) and SARS-CoV-2, the virus that causes COVID-19. Am J Trop Med Hyg. 2008 Sep. 24(9):396-400. Vaccine. Four serotypesof the virus have been found, a reported fifth has yet to be confirmed, all of which can cause the full spectrum of disease. 2008 Sep. 36(7):413-7. Abstract. Over all male population was mostly infected as compared to females and people in the age group between 15 to 45 was the highest infected group. 2009 Sep. 65(1):42-8. Clin Infect Dis. The incidence of dengue has grown dramatically around the world in recent decades. [Medline]. PLoS Negl Trop Dis. [Full Text]. [Medline]. Includes access to a companion web site offering the complete contents of the book - fully searchable - for rapid consultation from anyplace with an Internet connection. Participants from the coastal region were more likely to be positive for DENV IgG at the febrile visit than participants from the western region (19/420 4.5% vs. 7/568 1.2%; p = 0.003) (Table 1). Out of 100 patients, four had concurrent infection with two serotypes. Curr Infect Dis Rep. 2015 Jan. 17 (1):457. Michael Stuart Bronze, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Medical Association, Association of Professors of Medicine, Infectious Diseases Society of America, Oklahoma State Medical Association, Southern Society for Clinical InvestigationDisclosure: Nothing to disclose. Mosquitocidal vaccines: a neglected addition to malaria and dengue control strategies. Comparison of the FDA-approved CDC DENV-1-4 real-time reverse transcription-PCR with a laboratory-developed assay for dengue virus detection and serotyping. J Virol. Next- Generation Whole Genome Sequencing of … Knowledge of the spatial–temporal dynamics of dengue circulation throughout Africa is critically needed to inform a coordinated public health response in an increasingly interconnected world. serotypes, they are more genetically stable than many other RNA viruses, with an estimated 1 nucleotide change per year [11]. Our results confirm results of previous studies that showed overtreatment and diagnosis of malaria parasitemia (31,32). [Medline]. 2v; 5: Sample no. The Dengue virus in Nepal: gaps in diagnosis and surveillance. Features a new chapter on maternal immunization. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. An aliquot of whole blood from each participant was collected in Kenya. 91 (30):349-64. To the Editor: Dengue is the most prevalent arthropod-borne viral disease in tropical and subtropical countries. Response to dengue fever--the good, the bad, and the ugly?. Dengue is caused by four genetically differ-ent (DENV 1–4) serotypes of viruses (genus Flavivirus, family Flaviviridae). During 2016, we documented a DENV-4 cluster in samples from western Kenya and in 1 sample from coastal Kenya. The samples span July 2014–June 2017 and are derived from participants in coastal and western Kenya. Micah Lynne Trautwein Stanford UniversityDisclosure: Nothing to disclose. Authoritative and easily accessible, Dengue: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies on dengue research. Dengue vaccine: WHO position paper – July 2016. Found insidePathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * ... Suaya JA, Shepard DS, Siqueira JB, et al. estimated a burden of dengue disease in Africa similar to that in the Americas (>16% of the total global burden) (19). Privacy, Help [Medline]. CDC twenty four seven. 2005 Apr. [Medline]. [Medline]. Courtesy of the Centers for Disease Control and Prevention (CDC). Expert Rev Vaccines. [Medline]. Osterwell N. Dengue 'Under-recognized' as Source of Febrile Illness in US. J Thromb Haemost. A higher proportion of febrile children in the western region had dengue viremia than children in the coastal region (46.2% vs. 34.2%; p = 0.001). Exploring the origin and potential for spread of the 2013 dengue outbreak in Luanda, Angola. 2004 Apr. The findings of this study indicate that all four serotypes of dengue virus are circulating in Punjab whereas serotypes 2 and 3 introduced for the first time into Swat, KP in 2013; about 600 km away from Lahore, Punjab. J Clin Imaging Sci. Acute flavivirus and alphavirus infections among children in two different areas of Kenya, 2015. [Medline]. [Medline]. Dengue is a mosquito-borne seasonal viral infection, caused by four closely related viruses (DENV 1-4). Comprehensive demographic and household data were recorded. 11 (5):951-62. 2011 Mar. Figure 5. Am J Trop Med Hyg. Simmons CP, Farrar JJ, Nguyen V, Wills B. Dengue. Coexistence of different serotypes of dengue virus 39 (a) 10 8 6 E2 R2 4 E1 2 E0 0 0 2 4 6 8 10 R1 (b) 10 8 6 E2 E3 R2 4 2 E1 E0 0 0 2 4 6 8 10 R1 Fig. Travel-associated Dengue surveillance - United States, 2006-2008. Nevertheless, scientists' understanding of dengue virus may be simplistic, as rather than distinct antigenic groups, a continuum appear… It is based on a weakened combination of the yellow fever virus and each of the four dengue serotypes. Our results suggests high levels of dengue virus infection among children with undifferentiated febrile illness in Kenya. Dengue can be deadly, but with proper supportive care, most people beat the virus. They also are the only known arboviruses that have fully adapted to the human host and lost the need of an enzootic cycle for maintenance. There are four types of dengue virus (serotypes). Compilation of available DENV sequences from Africa into the phylogenetic analyses illustrates the dearth of sequences from Africa and is particularly evident for DENV-1 and DENV-4 (Figure 1). Evaluation of the NS1 rapid test and the WHO dengue classification schemes for use as bedside diagnosis of acute dengue fever in adults. 2006 Oct. 19(5):429-36. I got horribly sick. Available at https://www.who.int/emergencies/ten-threats-to-global-health-in-2019. Next- Generation Whole Genome Sequencing of Dengue Virus. Impact of Dengue. In addition, serotype circulation to the level of genotype is needed for assessing and predicting the efficacy of dengue vaccines. Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan. Characteristic of dengue disease in Taiwan: 2002-2007. Chebii, P. Maina), Diani Health Center, Ukunda, Kenya (Z. Jembe), California Academy of Sciences, San Francisco, California, USA (S.V. 353(9):877-89. Although many DENV epidemics have been associated with the alteration of predominant serotypes, the present study demonstrated that the new DENV-1 genotype invasion was typically the cause of dengue outbreaks in Guangzhou, particularly in 2006 and 2013–2014, whereas DENV-1 genotype II was the main epidemic genotype in 2003 and before. Each DENV serotype (DENV-1, DENV-2, DENV-3, and DENV-4) is structured into major lineages referred to as genotypes which have been defined (5–7). Dengue is an important human viral disease transmitted by insects. Provinces and Districts hit by dengue virus in 2011 and 2013 in Pakistan.…, Gel photograph of the first round RT-PCR product. Bull World Health Organ. [Medline]. I don't know how. Kyle JL, Harris E. Global spread and persistence of dengue. Waduge R, Malavige GN, Pradeepan M, Wijeyaratne CN, Fernando S, Seneviratne SL. Am J Trop Med Hyg. Santhosh VR, Patil PG, Srinath MG, Kumar A, Jain A, Archana M. Sonography in the diagnosis and assessment of dengue Fever. A detailed understanding of the transmission dynamics of dengue on the population level would thus be necessary, to formulate possible intervention strategies to stave the onward transmission of dengue virus. 2006 Spring. We document DENV circulation in Kenya over a 4-year period interspersed with small outbreaks as described (17). Dengue is an emerging infection of tropical and subtropical regions caused by a group of four serotypes of dengue virus that are transmitted to … Flavivirus.It is caused by infection of one of the We provide the distribution of dengue serotypes over the study period (Figure 3). Found insideThe book therefore fills a gap in the neuroepidemiology literature, with chapters written by an international collection of experienced authors in the field. This illustrates the importance of MHC class I transcription regulation in primary infections by different DV serotypes that may have even greater impact in secondary infections, associated with increased disease severity. 113(7):946-51. MT076932–62. 2013). Epidemiol Infect. Rey JR. Dengue in Florida (USA). The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Clin Infect Dis. Library preparation was performed by using the Nextera XT DNA Library Preparation Kit (96 samples) and the Nextera XT Index Kit (96 indices, 384 samples) (both from Illumina, https://www.illumina.com) according to manufacturer’s instructions with modifications: 3 ng of input cDNA with 4 μL index was used per reaction (rather than the suggested 1 ng input with 5 μL index because of low cDNA concentrations). The number of illness days before seeking care was lower in the coastal region than in the western region (2.3 vs. 3.1 days; p<0.001). 496 (7446):504-7. [Full Text]. Inset map shows location of Kenya in Africa. An ELISA result positive for DENV IgG in serum was indicative of previous exposure. 2006 Jan. 74(1):142-7. 2008 Oct. 102(10):1011-6. The mean number of illness days before seeking care was 2 days (range 1–14 days). [Full Text]. [Full Text]. Antimalarial drug prescriptions were also more likely for DENV viremic patients (48.8% vs. 36.8%; p<0.001), although malaria smear positivity was not different between the groups (Table 2). [Medline]. Kong YY, Thay CH, Tin TC, Devi S. Rapid detection, serotyping and quantitation of dengue viruses by TaqMan real-time one-step RT-PCR. Testing of whole blood might have enabled detection of low-level viremia that would otherwise have not been detected in serum or plasma samples. China’s impact on Africa: the role of trade, FDI and aid. 1997 Dec. 25(6):1374-7. Shepard DS, Coudeville L, Halasa YA, Zambrano B, Dayan GH. WHO. Dengue virus (DENV) is the cause of dengue fever. Results: 83(4):308-14. Phase I clinical evaluation of rDEN4Delta30-200,201: a live attenuated dengue 4 vaccine candidate designed for decreased hepatotoxicity. 49(12):248-53. Out of 100 patients, four had concurrent infection with two serotypes. McArthur JH, Durbin AP, Marron JA, Wanionek KA, Thumar B, Pierro DJ, et al. Vaccine. Semin Nephrol. Disclaimer, National Library of Medicine -, Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, et al. [Medline]. Found insideThis is a multi-authored book concerning the perceived threat and recorded increase of emerging pests and vector-borne diseases affecting man and animals in Europe.Historically, Europe suffered from numerous pests and vector-borne diseases, ... Studies designed to estimate dengue disease incidence and how febrile illness surveys can be extrapolated to estimate incidence are lacking. We postulate that viral strains related to the Thailand 1964 strain might be circulating at low levels in Kenya, but further surveillance for DENV-1 in other regions of Kenya and Africa is needed. [Medline]. The dengue viruses, of which four serotypes are known (DV-1, -2, -3, and -4), are the most widespread arthropod-borne viruses (arboviruses). [Medline]. Children in Kenya who had undifferentiated febrile illness from 4 outpatient clinics located in Chulaimbo, Kisumu, Msambweni, and Ukunda were enrolled during January 24, 2014–August 15, 2017 (Figure 2). The Dengue Serotypes Dengue infections are caused by four closely related viruses named DEN-1, DEN-2, DEN-3, and DEN-4. 6 (8):e1760. [Medline]. Dengue is a pathogenic mosquito-borne virus belonging to the Flaviviridae family that causes 390 million infections per year. Dengue virus serotype 2 and 3 causing high morbidity and mortality in Swat, Pakistan. Each 25-μL reaction contained LongAmp Hot Start Taq 2× Master Mix (New England BioLabs, https://www.neb.com), 400 nmol/L of forward and reverse primers, 3% dimethyl sulfoxide, and 5 μL of cDNA. Immunopathogenesis of Dengue hemorrhagic fever. Acutely ill febrile children were recruited from 4 clinical sites in western and coastal Kenya, and 1,022 participant samples were tested by using a highly sensitive real-time reverse transcription PCR. Blood from each of the study participants was collected for serologic analysis, molecular testing, and malaria parasite smear. 2 t; 7: Sample no. cDNA was purified by using the Zymo Clean and Concentrator Kit (Zymo Research, https://www.zymoresearch.com). [Medline]. [Medline]. 2014 Mar. Accessed: October 20, 2011. This increases the risk of Severe Dengue and, therefore, death. Singh N, Sharma KA, Dadhwal V, Mittal S, Selvi AS. Figure 6. 2008 Jul. Amugongo), Msambweni County Referral Hospital, Msambweni, Kenya (P.K. Poor appetite was more often reported in dengue patients than in children without dengue (46.8% vs. 36.3%; p = 0.001). Stephenson JR. Understanding dengue pathogenesis: implications for vaccine design. In addition, the number of concomitant serotype infections was also high and unexpected. 2004 Oct. 10(10):1872-3. "There are four serotypes of dengue virus, all of which can cause disease, including dengue fever, dengue shock syndrome [and] dengue hemorrhagic fever. 2011 Apr. Lancet. In the past 30 years, dengue transmission and the frequency of dengue epidemics have increased greatly in most tropical countries in the American region."--Page [1]. Isolation of DENV-1 and DENV-2 in Africa was made in Nigeria during 1968 (8). Lima EQ, Nogueira ML. 2x, representing DENV-2. Lahiri M, Fisher D, Tambyah PA. Dengue mortality: reassessing the risks in transition countries. Lancet. Domingo C, de Ory F, Sanz JC, Reyes N, Gascón J, Wichmann O, et al. Trung DT, Thao le TT, Hien TT, et al. Each child 1–17 years of age who came for care (Monday–Friday) because of an acute febrile illness (defined as reported illness during the previous 14 days and current observed temperature >38°C) and no localizing symptoms were recruited. mosquitoes. Chen WS, Wong CH, Cillekens L. Dengue antibodies in a suburban community in Malaysia. Wilson ME, Chen LH. Dengue is transmitted to humans through the bite of certain species of Aedes mosquitos that carry one of the virus’s four serotypes: dengue viruses 1–4. Found insideCovers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria and insects ... this new ed. has been extensively revised and updated to reflect the 50 % increase in identified and accepted viruses since ... Clin Microbiol. Available at http://www.who.int/topics/dengue/en/. The dengue virus has 4 related but antigenically distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. Halstead SB. 363(5):484-7. Dengue fever is the most common arbovirus in the world, and all four serotypes are infectious and pathogenic, but dengue virus (DENV)-1 and DENV-2 are the most prevalent in Guangdong Province. The findings of this study indicate that all four serotypes of dengue virus are circulating in Punjab whereas serotypes 2 and 3 introduced for the first time into Swat, KP in 2013; about 600 km away from Lahore, Punjab. eCollection 2016. [Medline]. Dengue is an acute febrile disease caused by the mosquito-borne dengue viruses (DENVs), consisting of four serotypes (DENV 1 to 4), that are members of the flaviviridaefamily, genus flavivirus (1). ( range 1–14 days ) out of Medscape ( 9 ): e0154760 and use of.! Scott TW, Zou C, Pigott DM, Duda KA, Thumar B Pierro! The circulation of DENV-1 and DENV-2 in Africa than previously recognized ( 2 ) long and history! Studies suggest wider dengue circulation in Africa than previously recognized ( 2 ):151-154. doi: 10.3343/alm.2017.37.2.151: ;. 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